A1 and A2 Bovine Milk, the Risk of Beta-casomorphin-7 and Its Possible Effects on Human Health:(I) A1 and A2 Milk and the Risk of Beta-casomorphin-7
Abstract
Milk proteins are generally composed of proteins such as casein, lactalbumin, lactoglobulin, blood serum albumin, and immunoglobulin. One of them, casein from milk proteins consists of fractions such as alpha, beta, kappa and gamma.
Beta casein gene in cattle consists of 209 amino acids and contains proline amino acid (CCT) at position 67 of the amino acid sequence. The milk obtained from animals with this genotype is defined as the original A2 milk. Proline/Histidine amino acid substitution (C/A) at position 67 of the amino acid sequence results in the beta-casomorphine-7 (BCM-7) which is a naturally occurring opioid peptide from cow’s milk. By this substitution (CAT), the milk obtained from animals with genotypes (A1A1 or A1A2) is defined as the A1 milk. BCM-7 is a polypeptide consisting of seven amino acids and is produced from A1 milk during digestion of beta-casein protein. As a result, BCM-7 has harmful effects on human health.
The aim of this study is to raise awareness in the field of animal science as well as to contribute to the taking of professional measures by using the literature on A1 / A2 milk and beta-casomorphine-7.Keywords
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Anonymous (2018). What is A2 Milk. http://www.shreshthafarms.com/a2-milk Ac-cession Date: [30.10.2018].
Brantl V, Teschemacher H., Henschen A. & Lottspeich F (1979). Novel opioid peptides derived from casein (β-casomorphins). I. Isolation from bo-vine casein peptone, Hoppe-Seylers Zeitschrift für physiologische Chemie 360(2): 1211-1224.
Beavers, L. & van Doormaal, B. 2016. Beta Casein, A2 Milk and Genetics. Canadian Dairy Net-work. www.cdn.ca/document.php?id=461. Ac-cession Date: [30.10.2018]
Boro P, Naha BC, Saikia DP & Prakash C (2016). A1 and A2 milk & its impact on human health. International Journal of Science and Nature 7(1): 01-05.
Caroli A, Chessa S & Erhardt G (2009). Invited review: Milk protein polymorphisms in cattle: Effect on animal breeding and human nutrition, Journal of dairy science 92(11): 5335-5352.
Chang KJ, Su YF, Brent DA & Chang J (1985). Isola-tion of a specific mu-opiate receptor peptide, morphiceptin, from an enzymatic digest of milk proteins. Journal of Biological Chemistry 260 (17): 9706-9712.
Clemens RA (2011). Milk A1 and A2 peptides and diabetes, In: Milk and Milk Products in Human Nutrition, Eds: Karger Publishers, p. 187-195.
De S, Paradkar P & Vaidya A (2015). Indian Breed Cow Milk-Powerhouse of Health. https://www.researchgate.net/profile/Suparna_De3/publication/281430281_Indian_Breed_Cow_Milk_-_Powerhouse_of_Health/links/55e699e408aecb1a7ccd6e98.pdf
Dinc H, Ozkan, E, Koban E & Togan I (2013). Beta-casein A1/A2, kappa-casein and beta-lactoglobulin polymorphisms in Turkish cattle breeds. Archives Animal Breeding 56(1): 650-657.
Eigel W, Butler J, Ernstrom C, Farrell Jr H, Harwalkar V, Jenness R & Whitney R M (1984) Nomencla-ture of proteins of cow's milk: Fifth revision1. Journal of Dairy Science 67(8): 1599-1631.
Elliott R, Harris D, Hill J, Bibby N & Wasmuth H, (1999) Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consump-tion. Diabetologia 42(3): 292-296.
Farrell Jr H, Jimenez-Flores R, Bleck G, Brown E, Butler J, Creamer L, Hicks C, Hollar C, Ng-Kwai-Hang K & Swaisgood H (2004) Nomenclature of the proteins of cows’ milk—Sixth revision. Journal of Dairy Science 87(6): 1641-1674.
Ganguly I, Gaur G, Singh U, Kumar S, Kumar S & Mann S (2013). Beta-casein (CSN2) polymor-phism in Ongole (Indian zebu) and Frieswal (HF× Sahiwal crossbred) cattle. Indian Journal of Biotechnology 12(2): 195-198.
Groves M (1969). Some minor components of casein and other phosphoproteins in milk. A review, Journal of Dairy Science 52(8): 1155-1165.
Hanusová E, Huba J, Oravcová M, Polák P & Vrtková I (2010). Genetic variants of beta-casein in Hol-stein dairy cattle in Slovakia. Slovak Journal of Animal Science (Slovak Republic), (2):63-66
Ho S, Woodford K, Kukuljan S & Pal S (2014). Com-parative effects of A1 versus A2 beta-casein on gastrointestinal measures: a blinded randomised cross-over pilot study. European journal of clinical nutrition 68(9): 994-1000.
Jaiswal KP, De S & Sarsavan A (2014). Review on bovine beta-casein (A1, A2) gene polymor-phism and their potentially hazardous on hu-man health. International Journal of Environ-ment & Animal Conservation 03(01): 1-12.
Jinsmaa Y & Yoshikawa M (1999). Enzymatic release of neocasomorphin and β-casomorphin from bovine β-casein. Peptides 20(8): 957-962.
Kamiński S, Cieślińska A & Kostyra E (2007). Poly-morphism of bovine beta-casein and its poten-tial effect on human health. Journal of applied Genetics, 48(3): 189-198.
Kostyra E, Kostyra H, Jarmolowska B & Krawczuk S, (2002). Tetrahymena termophila as a source of the opioid receptors for testing of opioid pep-tides. Polish Journal of Environmental Studies 11(6): 707-712.
Kostyra E, Sienkiewicz-Szłapka E, Jarmołowska B, Krawczuk S & Kostyra H (2004). Opioid pep-tides derived from milk proteins. Polish journal of food and nutrition sciences 13 (Suppl. 1): 25-35.
Kurek M, Przybilla B, Hermann K & Ring I (1992). A naturally occurring opioid peptide from cow’s milk, beta-casomorphine-7, is a direct histamine releaser in man. International archives of aller-gy and immunology. 97(2): 115-120.
Mallepalli S, Kumar R K & Sriram N (2017). Difference between A1 and A2 milk: Risk of A1 milk. In-ternational Journal of Allied Medical Sciences and Clinical Research (IJAMSCR) 5 (1): 163-167.
McLachlan C (2001). β-casein A1, ischaemic heart disease mortality, and other illnesses. Medical Hypotheses 56(2): 262-272.
Miluchová M, Gábor M & Trakovická A (2014). Anal-ysis of beta-casein gene (CSN2) polymorphism in different breeds of cattle. Scientific Papers Animal Science and Biotechnologies 47 (2), 56-59.
Mishra B, Mukesh M, Prakash B, Sodhi M, Kapila R, Kishore A, Kataria R, Joshi B, Bhasin V & Ra-sool T (2009). Status of milk protein, b-casein variants among Indian milch animals, Indian J Anim Sci 79: 722-725.
Ng-Kwai-Hang K & Grosclaude F (2003). Genetic pol-ymorphism of milk proteins, In: Advanced Dairy Chemistry—1 Proteins, Eds: Springer, p. 739-816.
Nguyen DD, Johnson SK, Busetti F & Solah VA, (2015). Formation and degradation of beta-casomorphins in dairy processing, Critical Re-views in Food Science and Nutrition 55(14): 1955-1967.
Pal S, Woodford K, Kukuljan S & Ho S (2015). Milk intolerance, beta-casein and lactose. Nutrients, 7(9): 7285-7297.
Parashar A & Saini R K (2015). A1 milk and its con-troversy-a review. International Journal of Bi-oassays, 4(12): 4611-4619.
Rahman S M, Islam A, Alam M M, Hossain M M K, Alim MA, Salimmullah M & Alam J (2016). Analysis of Beta-casein gene variants of milk in cattle. https://www.researchgate.net/profile /Jahangir_Alam/publication/307174687_Analysis_of_Beta-casein_gene_variants_of_milk_in_ cattle/links/57c4126208aee5141be5b488/ Analysis-of-Beta-casein-gene-variants-of-milk-in-cattle.pdf
Rijnkels M (2002). Multispecies comparison of the casein gene loci and evolution of casein gene family. Journal of Mammary Gland Biology and Neoplasia 7(3): 327-345.
Roginski H (2003). Encyclopedia of dairy sciences. Academic Press, London.
Sodhi M, Mukesh M, Mishra B, Kishore A, Prakash B, Kapil R, Khate K, Kataria R & Joshi B (2012). Screening of taurine and crossbred breeding bulls for A1/A2 variants of β-casein gene. The Indian Journal of Animal Sciences 82(1): 2-9.
Teschemacher H (2003). Opioid receptor ligands de-rived from food proteins. Current Pharmaceuti-cal Design 9(16): 1331-1344.
Truswell A (2005) The A2 milk case: a critical review, European journal of clinical nutrition, 59 (5), 623–631
Woodford K (2008). A1 Beta-casein, Type 1 Diabetes and Links to other Modern Illnesses Woodford paper to IDF Congress April 2008, 1-20.
DOI: https://doi.org/10.15316/SJAFS.2018.146
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