A1 and A2 Bovine Milk, the Risk of Beta-casomorphin-7 and Its Possible Effects on Human Health: (II) Possible Effects of Beta-casomorphin-7 on Human Health

Özcan Şahin, Saim Boztepe, İbrahim Aytekin


Beta-casomorphine-7 (BCM-7), which is an opioid peptide during digestion of A1 milk, has been claimed as a possible cause of some health problems. There are some studies about the role of β- casomorphine-7 in some diseases such as type 1 diabetes, cardiovascular diseases, autism, schizophrenia, sudden infant death syndrome, apnea, constipation. For example, β- casomorphine-7 destroys pancreatic β cells, leading to the emergence of type 1 diabetes. It affects T and B cells related to immunity and negatively affects the autoimmune system.

The aim of this study is to reveal the diseases that can caused by β- casomorphine-7 in terms of both animal and human health, in this way to contribute to the reduction of the costs of animal and human health and to create an awareness.


Beta casein, Beta-casomorphin 7, Bovine milk, Milk protein, A1 and A2 milk, Human health, Gene

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Boro P, Naha BC, Saikia DP & Prakash, C (2016) A1 and A2 milk & its impact on human health. International Journal of Science and Nature 7(1): 01-05.

Bell SJ, Grochoski, GT & Clarke AJ (2006). Health implications of milk containing β-casein with the A2 genetic variant. Critical Reviews in Food Science and Nutrition 46(1): 93-100.

Brantl V, Teschemacher H, Henschen A & Lottspeich F (1979). Novel opioid peptides derived from casein (β-casomorphins). I. Isolation from bo-vine casein peptone, Hoppe-Seyler s Zeitschrift für Physiologische Chemie 360(2): 1211-1224.

Brooks JG (1982). Apnea of infancy and sudden in-fant death syndrome, American Journal of Dis-eases of Children 136(11): 1012-1023.

Cade R, Wagemaker H, Privette R, Fregly M, Rogers J & Orlando J (1990) The effect of dialysis and diet on schizophrenia, Psychiatry: A World Per-spective 3(900): 494-500.

Cade R, Privette M, Fregly M, Rowland N, Sun Z, Zele V, Wagemaker H & Edelstein C (2000). Autism and schizophrenia: intestinal disorders. Nutri-tional Neuroscience 3(1): 57-72.

Elliott R, Harris D, Hill J, Bibby N & Wasmuth H, (1999). Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consump-tion. Diabetologia 42(3): 292-296.

Hartwig A, Gauly M, Erhardt G, Teschemacher H & Lehmann W (1997) Influence of genetic poly-morphisms in bovine milk on the occurrence of bioactiand peptides [beta-caso-morphins], Milk protein polymorphism, Palmerston North (New Zealand), Feb 1997.

Hedner J & Hedner T (1987). β-Casomorphins induce apnea and irregular breathing in adult rats and newborn rabbits. Life Sciences 41(20): 2303-2312.

Ho S, Woodford K, Kukuljan S & Pal S (2014). Com-parative effects of A1 versus A2 beta-casein on gastrointestinal measures: a blinded randomised cross-over pilot study. European Journal of Clinical Nutrition 68(9): 994.

Jaiswal KP, De S & Sarsavan A (2014). Review on bovine beta-casein (A1, A2) gene polymor-phism and their potentially hazardous on hu-man health. International Journal of Environ-ment & Animal Conservation 03 (01).

Jinsmaa Y & Yoshikawa M (1999b). Enzymatic re-lease of neocasomorphin and β-casomorphin from bovine β-casein. Peptides 20(8), 957-962.

Kamiński S, Cieślińska A & Kostyra E (2007). Poly-morphism of bovine beta-casein and its poten-tial effect on human health. Journal of Applied Genetics 48(3): 189-198.

Knivsberg A, Reichelt K, Høien T & Nødland M, (2002). A randomised, controlled study of die-tary intervention in autistic syndromes. Nutri-tional Neuroscience 5(4): 251-261.

Kost NV, Sokolov ОY, Kurasova ОB, Dmitriev AD, Tarakanova JN, Gabaeva МV, Zolotarev YA, Dadayan АK, Grachev SA & Korneeva ЕV (2009). β-Casomorphins-7 in infants on differ-ent type of feeding and different levels of psy-chomotor development. Peptides 30(10): 1854-1860.

Laugesen M & Elliott R (2003). Ischaemic heart dis-ease, Type 1 diabetes, and cow milk A1 β-casein. The New Zealand Medıcal Journal 116(1168): 1-19.

Lindström L, Nyberg F, Terenius L, Bauer K, Besev G, Gunne L, Lyrenäs S, Willdeck-Lund G & Lind-berg B (1984). CSF and plasma beta-casomorphin-like opioid peptides in postpartum psychosis. The American Journal of Psychiatry 141(9): 1059-1066.

McLachlan C (2001). β-casein A1, ischaemic heart disease mortality, and other illnesses. Medical Hypotheses 56 (2): 262-272.

Mishra B, Mukesh M, Prakash B, Sodhi M, Kapila R, Kishore A, Kataria R, Joshi B, Bhasin V & Ra-sool T (2009). Status of milk protein, b-casein variants among Indian milch animals. Indian J Anim Sci 79: 722-725.

Ng-Kwai-Hang K & Grosclaude F (2003). Genetic pol-ymorphism of milk proteins, In: Advanced Dairy Chemistry—1 Proteins, Eds: Springer, 739-816.

NIH (2010). Consensus Development Conference: Lactose Intolerance and Health February, 22–24.

Priyadarshini P, Mishra C, Mishra B, Swain K, Rout M & Mishra SP (2018). Impact of milk protein on human health: A1 verses A2, IJCS, 6 (1): 531-535.

Reichelt K, Ekrem J & Scott H (1990) Gluten, milk proteins and autism: dietary intervention effects on behavior and peptide secretion. Journal of Applied Nutrition 42 (1): 1-11.

Reichelt KL, Knivsberg A-M, Lind G & Nødland, M., (1991). Probable etiology and possible treat-ment of childhood autism. Brain Dysfunction.

Sodhi M, Mukesh M, Mishra B, Kishore A, Prakash B, Kapil R, Khate K, Kataria R & Joshi B (2012). Screening of taurine and crossbred breeding bulls for A1/A2 variants of β-casein gene. The Indian Journal of Animal Sciences 82(1): 2-9.

Sun Z, Cade JR, Fregly MJ & Privette RM (1999). β-Casomorphin induces Fos-like immunoreactivi-ty in discrete brain regions relevant to schizo-phrenia and autism. Autism 3(1): 67-83.

Sun Z, Cade RJ (1999). A peptide found in schizo-phrenia and autism causes behavioural changes in rats. Autism 3(1): 85-95.

Sun, Z., Zhang, Z., Wang, X., Cade, R., Elmir, Z. and Fregly, M., 2003, Relation of β-casomorphin to apnea in sudden infant death syndrome, Pep-tides, 24 (6): 937-943.

Swinburn B (2004). Beta casein A1 and A2 in milk and human health. Report to New Zealand Food Safety Authority, 1-43

Tailford KA, Berry CL, Thomas AC & Campbell JH, (2003). A casein variant in cow's milk is athero-genic. Atherosclerosis 170(1): 13-19.

Wasilewska J, Sienkiewicz-Szłapka E, Kuźbida E, Jar-mołowska B, Kaczmarski M & Kostyra E (2011). The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE). Neuropeptides 45(3): 189-195.

Whiteley P, Haracopos D, Knivsberg A-M, Reichelt KL, Parlar S, Jacobsen J, Seim A, Pedersen L, Schondel M & Shattock P (2010). The ScanBrit randomised, controlled, single-blind study of a gluten-and casein-free dietary intervention for children with autism spectrum disorders. Nutri-tional Neuroscience 13(2): 87-100.

Woodford K (2011). Milk Proteins and Human Health: A1 Versus A2 Beta-Casein, GPCE, Sydney, 1-6.

Woodford KB (2007). A2 milk, farmer decisions, and risk management, Proceedings of the 16th In-ternational Farm Management Congress: Peer reviewed papers, 641-648

DOI: https://doi.org/10.15316/SJAFS.2018.147


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